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BMC Public Health

, 12:968

Infectious Disease epidemiology

Abstract

BackgroundInfluenza illness in children causes significant clinical and economic burden. Although some European countries have adopted influenza immunisation policies for healthy children, the debate about paediatric influenza vaccination in most countries of the European Union is ongoing. Our aim was to summarise influenza burden in terms of health outcomes and economic burden in children in Western Europe via a systematic literature review.

MethodsWe conducted a systematic literature search of PubMed, EMBASE, and the Cochrane Library 1970-April 2011 and extracted data on influenza burden in children defined as aged ≤ 18 years from 50 publications 13 reporting laboratory-confirmed influenza; 37 reporting influenza-like illness.

ResultsChildren with laboratory-confirmed influenza experienced hospitalisations 0.3%-20%, medical visits 1.7-2.8 visits per case, antibiotic prescriptions 7%-55%, and antipyretic or other medications for symptomatic relief 76%-99%; young children and those with severe illness had the highest rates of health care use. Influenza in children also led to absenteeism from day care, school, or work for the children, their siblings, and their parents. Average mean or median length of absence from school or day care associated with confirmed influenza ranged from 2.8 to 12.0 days for the children, from 1.3 to 6.0 days for their siblings, and from 1.3 to 6.3 days for their parents. Influenza negatively affected health-related quality of life in children with asthma, including symptoms and activities; this negative effect was smaller in vaccinated children than in non-vaccinated children.

ConclusionsInfluenza burden in children is substantial and has a significant direct impact on the ill children and an indirect impact on their siblings and parents. The identified evidence regarding the burden of influenza may help inform both influenza antiviral use in children and paediatric immunisation policies in European countries.

KeywordsInfluenza Children Vaccination Europe Burden Electronic supplementary materialThe online version of this article doi:10.1186-1471-2458-12-968 contains supplementary material, which is available to authorized users.

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Autor: Evgeniya N Antonova - Catherine E Rycroft - Christopher S Ambrose - Terho Heikkinen - Nicola Principi

Fuente: https://link.springer.com/







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