Brain Levels of Catalase Remain Constant through Strain, Developmental, and Chronic Alcohol ChallengesReportar como inadecuado

Brain Levels of Catalase Remain Constant through Strain, Developmental, and Chronic Alcohol Challenges - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Enzyme ResearchVolume 2012 2012, Article ID 572939, 6 pages

Research ArticleBiology Department, Monmouth University, West Long Branch, NJ 07764, USA

Received 30 April 2012; Accepted 28 June 2012

Academic Editor: H. Kuhn

Copyright © 2012 Dennis E. Rhoads et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Catalase EC oxidizes ethanol to acetaldehyde within the brain and variations in catalase activity may underlie some consequences of ethanol consumption. The goals of this study were to measure catalase activity in subcellular fractions from rat brain and to compare the levels of this enzyme in several important settings. In the first series of studies, levels of catalase were compared between juvenile and adult rats and between the Long-Evans LE and Sprague-Dawley SD strains. Levels of catalase appear to have achieved the adult level by the preadolescent period defined by postnatal age P, days P25–P28, and there were no differences between strains at the developmental stages tested. Thus, variation in catalase activity is unlikely to be responsible for differences in how adolescent and adult rats respond to ethanol. In the second series of studies, periadolescent and adult rats were administered ethanol chronically through an ethanol-containing liquid diet. Diet consumption and blood ethanol concentrations were significantly higher for periadolescent rats. Catalase activities remained unchanged following ethanol consumption, with no significant differences within or between strains. Thus, the brain showed no apparent adaptive changes in levels of catalase, even when faced with the high levels of ethanol consumption characteristic of periadolescent rats.

Autor: Dennis E. Rhoads, Cherly Contreras, and Salma Fathalla



Documentos relacionados