A Case of REM Sleep Behavior Disorder, Narcolepsy-Cataplexy, Parkinsonism, and Rheumatoid ArthritisReportar como inadecuado

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Behavioural Neurology - Volume 2014 2014, Article ID 572931, 6 pages -

Case Report

Department of Neurology I.C., Sleep Research Centre, Oasi Institute for Research on Mental Retardation and Brain Aging IRCCS, Via C. Ruggero 73, 94018 Troina, Italy

Institute of Neurological Sciences, National Research Council, 95126 Catania, Italy

Department of Biomedical and Neuromotor Sciences, University of Bologna and IRCCS Istituto delle Scienze Neurologiche di Bologna, 40123 Bologna, Italy

Department of Psychiatry, Minnesota Regional Sleep Disorders Center, Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, MN 55415, USA

Received 21 January 2013; Accepted 13 March 2013; Published 18 February 2014

Academic Editor: Stefano F. Cappa

Copyright © 2014 Filomena I. I. Cosentino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A patient is reported in whom signs and symptoms of REM sleep behavior disorder RBD and narcolepsy have been associated for almost two decades with a late development of parkinsonism and rheumatoid arthritis. A 78-year-old male patient in whom RBD was first diagnosed was followed-up by clinical examination, video-polysomnography, multiple sleep latency test, cerebral magnetic resonance imaging, and dopamine transporter imaging by single-photon emission computerized tomography. The patient was found to present for almost two decades, in addition to RBD, also narcolepsy. Moreover, a late development of parkinsonism and the occurrence of rheumatoid arthritis were detected and clinically and instrumentally characterized. Patients predisposed to RBD and later parkinsonism might be susceptible to a variety of triggers that, in our patient, might have been represented by a possible latent autoimmune process leading to the development of narcolepsy with cataplexy and rheumatoid arthritis, later.

Autor: Filomena I. I. Cosentino, Angela Distefano, Giuseppe Plazzi, Carlos H. Schenck, and Raffaele Ferri

Fuente: https://www.hindawi.com/


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