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glutamine, MRS, cortisol, glutamate, spectroscopy

Bhardwaj, Paramjit Paul

Supervisor and department: Coupland, Nicholas Psychiatry

Examining committee member and department: Baker, Glen Psychiatry Hegadoren, Kathleen Nursing

Department: Department of Psychiatry


Date accepted: 2009-10-09T16:09:17Z

Graduation date: 2009-11

Degree: Master of Science

Degree level: Master's

Abstract: In rodents, stress and corticosteroids rapidly increase excitatory neurotransmission. During excitatory neurotransmission, glutamate concentrations are maintained by conversion of glutamine to glutamate. The hypothesis was that cortisol would alter human prefrontal glutamine or glutamate concentrations. Glutamine and glutamate were measured in prefrontal cortex n = 12 using 3.0 Tesla proton magnetic resonance spectroscopy 1H-MRS before and after intravenous cortisol hydrocortisone 35mg, in a randomized, double blind, placebo-controlled, within-subjects design. Glutamine decreased following cortisol compared with placebo session by time, F2,22 = 5.51; p = 0.012, whereas glutamate did not change F4,44 = 0.71; p = 0.59. Glutamine may be utilized to maintain glutamate concentrations during increased excitatory neurotransmission following cortisol. A limitation is that 1H-MRS does not measure metabolic flux rates directly. The effects of cortisol on glutamine could be a useful measure of altered central glucocorticoid responses in psychiatric disorders.

Language: English

DOI: doi:10.7939-R3DK5B

Rights: Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.

Autor: Bhardwaj, Paramjit Paul



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