Primary central nervous system angiosarcoma: two case reportsReport as inadecuate

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Journal of Medical Case Reports

, 6:251

First Online: 21 August 2012Received: 10 August 2011Accepted: 02 March 2012DOI: 10.1186-1752-1947-6-251

Cite this article as: Hackney, J.R., Palmer, C.A., Riley, K.O. et al. J Med Case Reports 2012 6: 251. doi:10.1186-1752-1947-6-251


IntroductionPrimary angiosarcoma of the brain is extremely rare; only 15 cases have been reported in adults over the last 25 years.

Case presentationsWe describe two cases of primary angiosarcoma of the brain that are well characterized by imaging, histopathology, and immunohistochemistry. Case 1: our first patient was a 35-year-old woman who developed exophthalmos. Subtotal resection of a left extra-axial retro-orbital mass was performed. Case 2: our second patient was a 47-year-old man who presented to our facility with acute visual loss, word-finding difficulty and subtle memory loss. A heterogeneously-enhancing left sphenoid wing mass was removed. We also review the literature aiming at developing a rational approach to diagnosis and treatment, given the rarity of this entity.

ConclusionsGross total resection is the standard of care for primary angiosarcoma of the brain. Adjuvant radiation and chemotherapy are playing increasingly recognized roles in the therapy of these rare tumors.

KeywordsAngiosarcoma Primary Central Nervous System CNS Tumors Sarcoma Bevacizumab Temozolomide Electronic supplementary materialThe online version of this article doi:10.1186-1752-1947-6-251 contains supplementary material, which is available to authorized users.

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Author: James R Hackney - Cheryl Ann Palmer - Kristen O Riley - Joel K Cure - Hassan M Fathallah-Shaykh - Louis B Nabors



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