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Journal of Medical Case Reports

, 6:217

First Online: 23 July 2012Received: 09 March 2012Accepted: 23 July 2012DOI: 10.1186-1752-1947-6-217

Cite this article as: La Mantia, E., Cantile, M., Liguori, G. et al. J Med Case Reports 2012 6: 217. doi:10.1186-1752-1947-6-217


IntroductionBreast involvement by non-Hodgkin lymphoma is particularly rare in men. We describe the case of a patient with a rapidly growing, painless gynecomastia-like nodule in the left breast. On ultrasonography, the nodule was suspicious for breast carcinoma.

Case presentationA breast biopsy from a 54-year-old Caucasian man showed the morphoimmunophenotypical features of grade 3 follicular lymphoma. Moreover, fluorescence in situ hybridization analysis showed a t14,18 translocation suggesting breast involvement by a systemic lymphoma rather than a primary breast lymphoma. The histological diagnosis was subsequently confirmed after nodule excision. Mediastinal and abdominal node involvement was then identified on computed tomography and positron emission tomography scans during staging examinations. Our patient was treated with chemotherapy. After three years our patient experienced a right retro-areolar relapse. He then received two further cycles of chemotherapy but developed a myeloid acute leukemia and, as a result of this, he subsequently died.

ConclusionsThe rarity of breast lymphomas, especially in men, and the problems related to the therapeutic choices with these tumors require molecular techniques in association with classical histological diagnosis.

KeywordsFollicular lymphoma Male breast t14;18 translocation Electronic supplementary materialThe online version of this article doi:10.1186-1752-1947-6-217 contains supplementary material, which is available to authorized users.

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Autor: Elvira La Mantia - Monica Cantile - Giuseppina Liguori - Maurizio Di Bonito - Annarosaria De Chiara - Massimiliano D-Aiuto -


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