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Tobacco Induced Diseases

, 10:9

First Online: 20 June 2012Received: 30 March 2012Accepted: 09 June 2012DOI: 10.1186-1617-9625-10-9

Cite this article as: Berlin, I., Lin, S., Lima, J.A.C. et al. Tob. Induced Dis. 2012 10: 9. doi:10.1186-1617-9625-10-9

Abstract

BackgroundCurrent smoking is associated with type 2 diabetes mellitus and impaired glucose tolerance but its association with the metabolic syndrome metS, particularly with sufficiently sampled African American representation, has not been clearly established.

ObjectiveTo assess whether a metS is associated with smoking; b any increased risk of metS among smokers is independent of body mass index BMI compared with non-smokers; c smoking status is differentially associated with the metS and its components across different ethnic groups.

MethodsCross sectional analysis of the Multi-Ethnic Study of Atherosclerosis MESA a community population-based sample free of cardiovascular disease.

ResultsCurrent smokers N = 769 had higher risk of metS odds ratio OR, 95% confidence interval: 1.4, 1.1-1.7 versus never reference, N = 2981 and former smokers 1.0, 0.8-1.1, N = 2163 and for metS components: high waist circumference WC OR:1.9, 1.2-2.1, low high density lipoprotein cholesterol HDL-C 1.5, 1.3-1.8, elevated plasma triglycerides TG OR:1.4, 1.2-1.7 as well as high C-reactive protein CRP, an inflammatory marker concentration OR: 1.6,1.3-2.0 compared to never and former smokers after adjustment for BMI. A smoking status by ethnicity interaction occurred such that African American current and former smokers had greater likelihood of low HDL-C than White counterparts.

ConclusionsThis study found that smoking is associated with the metS and despite the lower BMI of current smokers the prevalence of low HDL-C, elevated TG and CRP is higher among them than among non-smokers. African Americans generally have higher HDL-C than Whites but smoking wipes out this advantage.

Multi-Ethnic Study of Atherosclerosis MESA ClinicalTrials.gov Identifier: NCT00005487

KeywordsMetabolic syndrome Smoking Ethnic groups Body mass index  Download fulltext PDF



Autor: Ivan Berlin - Susan Lin - Joao A C Lima - Alain Gerald Bertoni

Fuente: https://link.springer.com/



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