Dynamics of circulating endothelial cells and endothelial progenitor cells in breast cancer patients receiving cytotoxic chemotherapyReportar como inadecuado

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BMC Cancer

, 12:620

Clinical oncology


BackgroundThe abundance of circulating endothelial cells CECs and circulating endothelial progenitor cells CEPs, which serve as surrogate markers for angiogenesis, may be affected by chemotherapy. We studied their dynamic change during consecutive cycles of chemotherapy.

MethodsWe collected blood samples from 15 breast cancer patients, who received a total of 56 courses of systemic chemotherapy, and measured the CECs, viable CECs V-CECs, and CEPs by six-color flow cytometry within the seven days prior to chemotherapy, twice a week during the first and second cycles of chemotherapy, and then once a week during the subsequent cycles.

ResultsThe CEC, V-CEC, and CEP levels all significantly decreased from day 1 of treatment to the first week of chemotherapy. After one week of chemotherapy, the CEC and V-CEC levels returned to a level similar to day 1. The CEP level remained significantly reduced after the first week of chemotherapy, but gradually rebounded until the next course of chemotherapy. After six cycles of chemotherapy, the total number of CEC and V-CEC cells trended toward a decrease and the CEP cells toward an increase. Clinical factors, including the existence of a tumor, chemotherapy regimens, and the use of granulocyte colony stimulating factor, did not significantly affect these results.

ConclusionsThe CEC and CEP counts change dynamically during each course of chemotherapy and after the chemotherapy cycles, providing background data for any future study planning to use CECs and CEPs as surrogate markers of angiogenesis in antiangiogenesis treatments combined with chemotherapy.

KeywordsCirculating endothelial cells Endothelial progenitor cells Breast cancer Angiogenesis Biomarkers Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-12-620 contains supplementary material, which is available to authorized users.

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Autor: Yu-Hsuan Kuo - Ching-Hung Lin - Wen-Yi Shau - Te-Jung Chen - Shih-Hung Yang - Shu-Min Huang - Chun Hsu - Yen-Shen Lu - Ann

Fuente: https://link.springer.com/

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