The clinical features of papillary thyroid cancer in Hashimoto’s thyroiditis patients from an area with a high prevalence of Hashimoto’s diseaseReport as inadecuate

The clinical features of papillary thyroid cancer in Hashimoto’s thyroiditis patients from an area with a high prevalence of Hashimoto’s disease - Download this document for free, or read online. Document in PDF available to download.

BMC Cancer

, 12:610

Clinical oncology


BackgroundThe goal of this study was to identify the clinicopathological factors of co-existing papillary thyroid cancer PTC in patients with Hashimoto’s thyroiditis HT and provide information to aid in the diagnosis of such patients.

MethodsThis study included 6109 patients treated in a university-based tertiary care cancer hospital over a 3-year period. All of the patients were categorised based on their final diagnosis. Several clinicopathological factors, such as age, gender, nodular size, invasive status, central compartment lymph node metastasis CLNM and serum thyroid-stimulating hormone TSH level, were compared between the various groups of patients.

ResultsThere were 653 patients with a final diagnosis of HT. More PTC was found in those with HT 58.3%; 381 of 653 than those without HT 2416 of 5456; 44.3%; p < 0.05. The HT patients with co-occurring PTC were more likely to be younger, be female, have smaller nodules and have higher TSH levels than those without PTC. A multivariate analysis indicated that the presence of HT and higher TSH levels were risk factors for a diagnosis of PTC. In the PTC patients, the presence of HT or another benign nodule was a protective factor for CLNM, whereas no significant association was found for TSH levels.

ConclusionPTC and HT have a close relationship in this region of highly prevalent HT disease. Based on the results of our study, we hypothesise that long-term HT leads to elevated serum TSH, which is the real risk factor for thyroid cancer.

KeywordsPapillary thyroid carcinoma Thyroid-stimulating hormone Hashimoto’s thyroiditis AbbreviationsPTCPapillary thyroid cancer

HTHashimoto’s thyroiditis

CLNMCentral compartment lymph node metastasis

TSHSerum thyroid stimulating hormone

fT3free triiodothyronine

fT4free thyroxine


OROdds rate

CLNDCentral lymph node dissection

GWASGenome-wide association studies

SDStandard deviation

CIConfidence intervals.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-12-610 contains supplementary material, which is available to authorized users.

Ling Zhang, Hui Li contributed equally to this work.

Download fulltext PDF

Author: Ling Zhang - Hui Li - Qing-hai Ji - Yong-xue Zhu - Zhuo-ying Wang - Yu Wang - Cai-ping Huang - Qiang Shen - Duan-shu Li -


Related documents