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Journal of Medical Case Reports

, 6:100

First Online: 04 April 2012Received: 18 October 2011Accepted: 04 April 2012DOI: 10.1186-1752-1947-6-100

Cite this article as: Daumas, A., El-Mekaoui, F., Bataille, S. et al. J Med Case Reports 2012 6: 100. doi:10.1186-1752-1947-6-100


IntroductionLegionnaires- disease is recognized as a multi-systemic illness. Afflicted patients may have pulmonary, renal, gastrointestinal tract and central nervous system complications. However, renal insufficiency is uncommon. The spectrum of renal involvement may range from a mild and transient elevation of serum creatinine levels to anuric renal failure requiring dialysis and may be linked to several causes. In our present case report, we would like to draw attention to the importance of the pathological documentation of acute renal failure by reporting a case of a patient with acute tubulointerstitial nephritis complicating Legionnaires- disease.

Case presentationA 55-year-old Caucasian man was admitted to our hospital for community-acquired pneumonia complicated by acute renal failure. Legionella pneumophila serogroup type 1 was diagnosed. Although the patient-s respiratory illness responded to intravenous erythromycin and ofloxacin therapy, his renal failure worsened, he became anuric, and hemodialysis was started. A renal biopsy was performed, which revealed severe tubulointerstitial nephritis. After initiation of steroid therapy, his renal function improved dramatically.

ConclusionsThis case highlights the importance of kidney biopsies in cases where acute renal failure is a complicating factor in Legionnaires- disease. If the presence of acute tubulointerstitial nephritis can be confirmed, it will likely respond favorably to steroidal treatment and thus irreversible renal damage and chronic renal failure will be avoided.

KeywordsLegionnaires- disease acute renal failure tubulointerstitial nephritis renal biopsy Electronic supplementary materialThe online version of this article doi:10.1186-1752-1947-6-100 contains supplementary material, which is available to authorized users.

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Autor: Aurélie Daumas - Fadwa El-Mekaoui - Stanislas Bataille - Laurent Daniel - Jean-Marie Caporossi - Pierre-Edouard Fournier -


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