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Tobacco Induced Diseases

, 10:2

First Online: 28 February 2012Received: 03 November 2011Accepted: 28 February 2012DOI: 10.1186-1617-9625-10-2

Cite this article as: Awaisu, A., Haniki Nik Mohamed, M., Noordin, N.M. et al. Tob. Induced Dis. 2012 10: 2. doi:10.1186-1617-9625-10-2


BackgroundWith evolving evidence of association between tuberculosis TB and tobacco smoking, recommendations for the inclusion of tobacco cessation interventions in TB care are becoming increasingly important and more widely disseminated. Connecting TB and tobacco cessation interventions has been strongly advocated as this may yield better outcomes. However, no study has documented the impact of such connection on health-related quality of life HRQoL. The objective of this study was to document the impact of an integrated TB directly observed therapy short-course DOTS plus smoking cessation intervention SCI on HRQoL.

MethodsThis was a multi-centered non-randomized controlled study involving 120 TB patients who were current smokers at the time of TB diagnosis in Malaysia. Patients were assigned to either of two groups: the usual TB-DOTS plus SCI SCIDOTS group or the usual TB-DOTS only DOTS group. The effect of the novel strategy on HRQoL was measured using EQ-5D questionnaire. Two-way repeated measure ANOVA was used to examine the effects.

ResultsWhen compared, participants who received the integrated intervention had a better HRQoL than those who received the usual TB care. The SCIDOTS group had a significantly greater increase in EQ-5D utility score than the DOTS group during 6 months follow-up mean ± SD = 0.98 ± 0.08 vs. 0.91 ± 0.14, p = 0.006. Similarly, the mean scores for EQ-VAS showed a consistently similar trend as the EQ-5D indices, with the scores increasing over the course of TB treatment. Furthermore, for the EQ-VAS, there were significant main effects for group F 1, 84 = 4.91, p = 0.029, η = 0.06, time F 2, 168 = 139.50, p = < 0.001, η = 0.62 and group x time interaction F 2, 168 = 13.89, p = < 0.001, η = 0.14.

ConclusionsThis study supports the evidence that an integrated TB-tobacco treatment strategy could potentially improve overall quality of life outcomes among TB patients who are smokers.

KeywordsDOTS Outcomes Quality of life Smoking cessation intervention Tuberculosis Electronic supplementary materialThe online version of this article doi:10.1186-1617-9625-10-2 contains supplementary material, which is available to authorized users.

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Autor: Ahmed Awaisu - Mohamad Haniki Nik Mohamed - Noorliza Mohamad Noordin - Abdul Razak Muttalif - Noorizan Abd Aziz - Syed Az


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