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Journal of Medical Case Reports

, 6:73

First Online: 27 February 2012Received: 07 September 2011Accepted: 27 February 2012DOI: 10.1186-1752-1947-6-73

Cite this article as: Sivrikoz, E., Ozbey, N.C., Kaya, B. et al. J Med Case Reports 2012 6: 73. doi:10.1186-1752-1947-6-73

Abstract

IntroductionAutopsy series have shown that metastasis to the thyroid gland has occurred in up to 24% of patients who have died of cancer. Neuroendocrine tumors may metastasize to thyroid gland.

Case presentationsCase 1 was a 17-year-old Turkish woman who was referred from our Endocrinology Department for a thyroidectomy for treatment of neuroendocrine tumor metastasis. She was treated with a bilateral total thyroidectomy. Histopathological examination results were consistent with a neuroendocrine tumor; neoplastic cells showed strong immunoreactivity to chromogranin A and synaptophysin, but the immunohistochemical profile was inconsistent with medullary thyroid carcinoma in that the tumor was negative for calcitonin, carcinoembryonic antigen, and thyroid transcription factor-1.

Case 2 was a 54-year-old Turkish woman who presented with a 3-cm nodule on her right thyroid lobe. She had undergone surgery for a right lung mass four years previously. After a right pneumonectomy, thymectomy and lymph node dissection, a typical carcinoid tumor was diagnosed. Under ultrasonographic guidance, fine needle aspiration biopsy of her right thyroid pole nodule was performed and the biopsy was compatible with a neuroendocrine tumor metastasis. She was treated with a bilateral total thyroidectomy. Histopathological examination indicated three nodular lesions, 5 cm and 0.4 cm in diameter in her right lobe and 0.1 cm in diameter in her left lobe. The tumors were consistent with a neuroendocrine phenotype, showing strong immunoreactivity to chromogranin A and synaptophysin.

ConclusionThyroid nodules detected during follow-up of neuroendocrine tumor patients should be thoroughly investigated. A fine needle aspiration biopsy of the thyroid confirms the diagnosis in most cases and leads to appropriate management of those patients and may prevent unnecessary treatment approaches.

Electronic supplementary materialThe online version of this article doi:10.1186-1752-1947-6-73 contains supplementary material, which is available to authorized users.

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Autor: Emre Sivrikoz - Nese Colak Ozbey - Bulent Kaya - Yesim Erbil - Serkan Kaya - Dilek Yilmazbayhan - Pinar Firat - Yersu Kap

Fuente: https://link.springer.com/







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