Effect of Ovariectomy on Stimulating Intracortical Remodeling in RatsReport as inadecuate

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BioMed Research International - Volume 2014 2014, Article ID 421431, 7 pages -

Research Article

Discipline of Oral Diagnosis and Polyclinics, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong

Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong

Department of Orthopedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong

Received 2 July 2014; Revised 29 August 2014; Accepted 5 September 2014; Published 21 September 2014

Academic Editor: Monica Fedele

Copyright © 2014 Chun Lei Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Technically primates and dogs represent ideal models to investigate diseases characterized by abnormal intracortical remodeling. High expenses and ethical issues, however, restrict the use of those animals in research. Rodent models have been used as alternatives instead, but their value is limited, if none, because these animals lack intracortical bone remodeling. This study aimed at investigating the effect of ovariectomy onto the stimulation of intracortical remodeling in rat mandibles. Materials and Methods. Sixteen 12-week-old Spraque-Dawly SD female rats were randomly assigned into two groups, receiving either ovariectomy or sham operation. All the rats were sacrificed 18 weeks postoperatively. The entire mandibles were harvested for microcomputed tomography micro-CT and histomorphometric assessments. Results. Micro-CT examination showed significantly decreased bone mineral density 0.95 ± 0.01 versus 1.01 ± 0.02 g-cm

, and bone volume 65.78 ± 5.45 versus 87.41 ± 4.12%, in ovariectomy group. Histomorphometric assessment detected a sixfold increased intracortical bone remodeling as well as an increased bone modeling in mandibles of ovariectomized rats. Conclusion. For the first time, to the authors’ knowledge, it was detected that ovariectomy stimulates intracortical remodeling in rat mandibles. This animal model might be of use to study various bone diseases associated with an abnormal intracortical remodeling process.

Author: Chun Lei Li, Xi Ling Liu, Wei Xin Cai, Weijia William Lu, Roger A. Zwahlen, and Li Wu Zheng

Source: https://www.hindawi.com/


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