T4SP Database 2.0: An Improved Database for Type IV Secretion Systems in Bacterial Genomes with New Online Analysis ToolsReportar como inadecuado

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Computational and Mathematical Methods in Medicine - Volume 2016 2016, Article ID 9415459, 4 pages -

Research Article

State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China

Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China

Received 31 May 2016; Revised 3 August 2016; Accepted 25 August 2016

Academic Editor: Daniel Zhao

Copyright © 2016 Na Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Type IV secretion system T4SS can mediate the passage of macromolecules across cellular membranes and is essential for virulent and genetic material exchange among bacterial species. The Type IV Secretion Project 2.0 T4SP 2.0 database is an improved and extended version of the platform released in 2013 aimed at assisting with the detection of Type IV secretion systems T4SS in bacterial genomes. This advanced version provides users with web server tools for detecting the existence and variations of T4SS genes online. The new interface for the genome browser provides a user-friendly access to the most complete and accurate resource of T4SS gene information e.g., gene number, name, type, position, sequence, related articles, and quick links to other webs. Currently, this online database includes T4SS information of 5239 bacterial strains. Conclusions. T4SS is one of the most versatile secretion systems necessary for the virulence and survival of bacteria and the secretion of protein and-or DNA substrates from a donor to a recipient cell. This database on virB-D genes of the T4SS system will help scientists worldwide to improve their knowledge on secretion systems and also identify potential pathogenic mechanisms of various microbial species.

Autor: Na Han, Weiwen Yu, Yujun Qiang, and Wen Zhang

Fuente: https://www.hindawi.com/


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