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Journal of Translational Medicine

, 10:191



BackgroundAs Chronic Fatigue Syndrome CFS has been known to follow Epstein-Bar virus EBV and other systemic infections; our objective was to describe differences in immune activation in post-infective CFS PI-CFS patients and recovered controls. We studied 301 adolescents prospectively over 24 months following the diagnosis of monospot-positive infectious mononucleosis IM. We found an incidence of CFS at 6, 12 and 24 months of 13%, 7% and 4% respectively.

MethodsUsing chemiluminescent imaging we measured the concentrations of IL-1a, 1b, 2, 4, 5, 6, 8, 10, 12 p70, 13, 15, 17 and 23, IFN-γ, TNF-α and TNF-β in duplicate plasma samples available in bio-bank from 9 PI-CFS subjects and 12 recovered controls at 24 months post-infection.

ResultsStandard comparative analysis indicated significant differences in IL-8 and 23 across subject groups. In constructing a linear classification model IL-6, 8 and 23 were selected by two different statistical approaches as discriminating features, with IL-1a, IL-2 and IFN-γ also selected in one model or the other. This supported an assignment accuracy of better than 80% at a confidence level of 0.95 into PI-CFS versus recovered controls.

ConclusionThese results suggest that co-expression patterns in as few as 5 cytokines associated with Th17 function may hold promise as a tool for the diagnosis of post-infectious CFS.

KeywordsCytokines Infectious mononucleosis Chronic fatigue Classification model Electronic supplementary materialThe online version of this article doi:10.1186-1479-5876-10-191 contains supplementary material, which is available to authorized users.

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Autor: Gordon Broderick - Ben Z Katz - Henrique Fernandes - Mary Ann Fletcher - Nancy Klimas - Frederick A Smith - Maurice RG 


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