Ligustrazine for the Treatment of Unstable Angina: A Meta-Analysis of 16 Randomized Controlled TrialsReportar como inadecuado




Ligustrazine for the Treatment of Unstable Angina: A Meta-Analysis of 16 Randomized Controlled Trials - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Evidence-Based Complementary and Alternative Medicine - Volume 2016 2016, Article ID 8617062, 11 pages -

Review Article

Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China

Department of Neurology, Nankai Hospital, Tianjin Academy of Integrative Medicine, Tianjin 300100, China

Department of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China

Department of Clinical Research, Nankai Hospital, Tianjin Academy of Integrative Medicine, Tianjin 300100, China

Editorial Department, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China

Received 26 October 2015; Revised 7 February 2016; Accepted 22 February 2016

Academic Editor: Stephanie Tjen-A-Looi

Copyright © 2016 Suman Cao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ligustrazine is a principal ingredient of chuanxiong. Concerns regarding the evaluation of the effectiveness of ligustrazine in the treatment of UA have resulted in a meta-analysis combined with recent clinical evidence. Seven computer databases that included the China hospital knowledge database CHKD, Wanfang Med Online, the Chinese medical journal database CMJD, PubMed, Cochrane, Embase Ovid, and Medline Ovid were systematically searched. We included randomized controlled trials and quasi-randomized controlled trials. Our systematic review identified 16 RCTs that met our eligibility criteria. Ligustrazine combined with conventional medicine was associated with an increased rate of marked improvement in symptoms and an increased rate of marked improvement of ECG compared with conventional Western medicine alone. Additionally, the use of ligustrazine was associated with significant trends in the reduction of the consumption of nitroglycerin and the level of fibrinogen when compared with conventional Western medicine alone. No firm results were found between the intervention and the control method groups in the reduction of the time of onset or the frequency of acute attack angina due to the high level of heterogeneity. In conclusion, our meta-analysis found that ligustrazine was associated with some benefits for people with unstable angina.





Autor: Suman Cao, Wenli Zhao, Huaien Bu, Ye Zhao, and Chunquan Yu

Fuente: https://www.hindawi.com/



DESCARGAR PDF




Documentos relacionados