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Environmental Health

, 10:S11

First Online: 05 April 2011DOI: 10.1186-1476-069X-10-S1-S11

Cite this article as: Bartsch, H., Arab, K. & Nair, J. Environ Health 2011 10Suppl 1: S11. doi:10.1186-1476-069X-10-S1-S11


BackgroundOxidative stress enhances lipid peroxidation LPO, which both are implicated in the promotion and progression stages of carcinogenesis, in particular under conditions of chronic inflammation and infections. Exocyclic etheno-DNA adducts, which are formed by LPO-products such as 4-hydroxy –2-nonenal, are strongly pro-mutagenic DNA lesions.

MethodsThe development of ultra-sensitive detection methods for etheno-adducts in human tissues, white blood cells WBC and urine has provided evidence that these adducts are elevated in affected organs of cancer-prone patients, probably acting as a driving force to malignancy.

ResultsTwo recent studies that yielded some new insights into disease causation are briefly reviewed:DNA-damage in WBC of mother-newborn child pairs, and lipid peroxidation derived DNA damage in patients with cancer-prone liver diseases. Our results indicate that biomonitoring of etheno-DNA adducts in humans are promising tools i to better understand disease aetiopathogenesis, allowing hazard identificationii to monitor disease progression and iii to verify the efficacy of chemopreventive and therapeutic interventions .Such clinical trials are warranted.

List of abbreviationsεdA1,N -ethenodeoxyadenosine


ALDalcohol-related disease

HBVhepatitis B virus

HCVhepatitis C virus

HCChepatocellar carcinoma


CYP2E1Cytochrome 2E1

ROSreactive oxygen species

LPOlipid peroxidation

CDDchronic degenerative diseases

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Autor: Helmut Bartsch - Khelifa Arab - Jagadeesan Nair


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