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Environmental Health

, 10:S11

First Online: 05 April 2011DOI: 10.1186-1476-069X-10-S1-S11

Cite this article as: Bartsch, H., Arab, K. & Nair, J. Environ Health 2011 10Suppl 1: S11. doi:10.1186-1476-069X-10-S1-S11

Abstract

BackgroundOxidative stress enhances lipid peroxidation LPO, which both are implicated in the promotion and progression stages of carcinogenesis, in particular under conditions of chronic inflammation and infections. Exocyclic etheno-DNA adducts, which are formed by LPO-products such as 4-hydroxy –2-nonenal, are strongly pro-mutagenic DNA lesions.

MethodsThe development of ultra-sensitive detection methods for etheno-adducts in human tissues, white blood cells WBC and urine has provided evidence that these adducts are elevated in affected organs of cancer-prone patients, probably acting as a driving force to malignancy.

ResultsTwo recent studies that yielded some new insights into disease causation are briefly reviewed:DNA-damage in WBC of mother-newborn child pairs, and lipid peroxidation derived DNA damage in patients with cancer-prone liver diseases. Our results indicate that biomonitoring of etheno-DNA adducts in humans are promising tools i to better understand disease aetiopathogenesis, allowing hazard identificationii to monitor disease progression and iii to verify the efficacy of chemopreventive and therapeutic interventions .Such clinical trials are warranted.

List of abbreviationsεdA1,N -ethenodeoxyadenosine

εdC3,N-ethenodeoxycytine

ALDalcohol-related disease

HBVhepatitis B virus

HCVhepatitis C virus

HCChepatocellar carcinoma

HNE4-hydroxy-2-nonenal

CYP2E1Cytochrome 2E1

ROSreactive oxygen species

LPOlipid peroxidation

CDDchronic degenerative diseases

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Autor: Helmut Bartsch - Khelifa Arab - Jagadeesan Nair

Fuente: https://link.springer.com/







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