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Journal of Nucleic AcidsVolume 2012 2012, Article ID 950508, 12 pages

Review Article

Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria

Division of Oncology, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria

Department for Companion Animals and Horses, Small Animal Internal Medicine, University of Veterinary Medicine Vienna, 1210 Vienna, Austria

Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA

Received 31 May 2011; Revised 27 July 2011; Accepted 7 August 2011

Academic Editor: Juan Valcarcel

Copyright © 2012 Klaus Holzmann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Alternative splicing of the IgIII loop of fibroblast growth factor receptors FGFRs 1–3 produces b- and c-variants of the receptors with distinctly different biological impact based on their distinct ligand-binding spectrum. Tissue-specific expression of these splice variants regulates interactions in embryonic development, tissue maintenance and repair, and cancer. Alterations in FGFR2 splicing are involved in epithelial mesenchymal transition that produces invasive, metastatic features during tumor progression. Recent research has elucidated regulatory factors that determine the splice choice both on the level of exogenous signaling events and on the RNA-protein interaction level. Moreover, methodology has been developed that will enable the in depth analysis of splicing events during tumorigenesis and provide further insight on the role of FGFR 1–3 IIIb and IIIc in the pathophysiology of various malignancies. This paper aims to summarize expression patterns in various tumor types and outlines possibilities for further analysis and application.





Autor: Klaus Holzmann, Thomas Grunt, Christine Heinzle, Sandra Sampl, Heinrich Steinhoff, Nicole Reichmann, Miriam Kleiter, Marlen

Fuente: https://www.hindawi.com/



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