Measuring the burden of arboviral diseases: the spectrum of morbidity and mortality from four prevalent infectionsReportar como inadecuado

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Population Health Metrics

, 9:1

First Online: 10 January 2011Received: 16 July 2010Accepted: 10 January 2011DOI: 10.1186-1478-7954-9-1

Cite this article as: LaBeaud, A., Bashir, F. & King, C.H. Popul Health Metrics 2011 9: 1. doi:10.1186-1478-7954-9-1


BackgroundGlobally, arthropod-borne virus infections are increasingly common causes of severe febrile disease that can progress to long-term physical or cognitive impairment or result in early death. Because of the large populations at risk, it has been suggested that these outcomes represent a substantial health deficit not captured by current global disease burden assessments.

MethodsWe reviewed newly available data on disease incidence and outcomes to critically evaluate the disease burden as measured by disability-adjusted life years, or DALYs caused by yellow fever virus YFV, Japanese encephalitis virus JEV, chikungunya virus CHIKV, and Rift Valley fever virus RVFV. We searched available literature and official reports on these viruses combined with the terms -outbreaks,-complications,-disability,-quality of life,-DALY,- and -QALY,- focusing on reports since 2000. We screened 210 published studies, with 38 selected for inclusion. Data on average incidence, duration, age at onset, mortality, and severity of acute and chronic outcomes were used to create DALY estimates for 2005, using the approach of the current Global Burden of Disease framework.

ResultsGiven the limitations of available data, nondiscounted, unweighted DALYs attributable to YFV, JEV, CHIKV, and RVFV were estimated to fall between 300,000 and 5,000,000 for 2005. YFV was the most prevalent infection of the four viruses evaluated, although a higher proportion of the world-s population lives in countries at risk for CHIKV and JEV. Early mortality and long-term, related chronic conditions provided the largest DALY components for each disease. The better known, short-term viral febrile syndromes caused by these viruses contributed relatively lower proportions of the overall DALY scores.

ConclusionsLimitations in health systems in endemic areas undoubtedly lead to underestimation of arbovirus incidence and related complications. However, improving diagnostics and better understanding of the late secondary results of infection now give a first approximation of the current disease burden from these widespread serious infections. Arbovirus control and prevention remains a high priority, both because of the current disease burden and the significant threat of the re-emergence of these viruses among much larger groups of susceptible populations.

List of abbreviationsCDCU.S. Centers for Disease Control and Prevention

CHIKVChikungunya virus

DALYDisability-adjusted life year

DENVDengue virus

DWDisability weight

JEVJapanese encephalitis virus

RVFVRift Valley fever virus

SEYLLStandard expected years of life lost

VHFViral hemorrhagic fever syndrome

WHOWorld Health Association

WNVWest Nile virus

YFVYellow fever virus

YLLYears of life lost

YLDYears lived with disability

Electronic supplementary materialThe online version of this article doi:10.1186-1478-7954-9-1 contains supplementary material, which is available to authorized users.

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Autor: ADesirée LaBeaud - Fatima Bashir - Charles H King


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