Myeloid-Derived microRNAs, miR-223, miR27a, and miR-652, Are Dominant Players in Myeloid RegulationReport as inadecuate

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BioMed Research InternationalVolume 2014 2014, Article ID 870267, 9 pages

Review Article

Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, Budapest 1089, Hungary

Division of Molecular and Cellular Science, The School of Pharmacy, University Park Science Road, Nottingham NG7 2RD, UK

Received 17 February 2014; Revised 29 June 2014; Accepted 16 July 2014; Published 11 August 2014

Academic Editor: Ming D. Li

Copyright © 2014 Anna B. Gilicze et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In the past few years expanding knowledge has been accumulated about the role of microRNAs miRNAs not only in hematopoiesis and cancer, but also in inflammatory and infectious diseases. Regarding myeloid cells, our knowledge is relatively insufficient, therefore we intended to collect the available data of miRNA profiles of myeloid cells. In addition to a rather general myeloid regulator miR-223, two other miRNAs seem to be useful subjects in understanding of myeloid miRNA biology: miR-27a and miR-652. We review functions of these three miRNAs and other myeloid miRNAs focusing on their roles in monocytes, neutrophils, eosinophils, basophils and mast cells.

Author: Anna B. Gilicze, Zoltán Wiener, Sára Tóth, Edit Buzás, Éva Pállinger, Franco H. Falcone, and András Falus



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