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Reproductive Health

, 11:S5

First Online: 26 September 2014DOI: 10.1186-1742-4755-11-S3-S5

Cite this article as: Lassi, Z.S., Imam, A.M., Dean, S.V. et al. Reprod Health 2014 11Suppl 3: S5. doi:10.1186-1742-4755-11-S3-S5


IntroductionA large proportion of women around the world suffer from chronic diseases including mental health diseases. In the United States alone, over 12% of women of reproductive age suffer from a chronic medical condition, especially diabetes and hypertension. Chronic diseases significantly increase the odds for poor maternal and newborn outcomes in pregnant women.

MethodsA systematic review and meta-analysis of the evidence was conducted to ascertain the possible impact of preconception care for preventing and managing chronic diseases and promoting psychological health on maternal, newborn and child health outcomes. A comprehensive strategy was used to search electronic reference libraries, and both observational and clinical controlled trials were included. Cross-referencing and a separate search strategy for each preconception risk and intervention ensured wider study capture.

ResultsMaternal prepregnancy diabetic care is a significant intervention that reduces the occurrence of congenital malformations by 70% 95% Confidence Interval CI: 59-78% and perinatal mortality by 69% 95% CI: 47-81%. Furthermore, preconception management of epilepsy and phenylketonuria are essential and can optimize maternal, fetal and neonatal outcomes if given before conception. Ideally changes in antiepileptic drug therapy should be made at least 6 months before planned conception. Interventions specifically targeting women of reproductive age suffering from a psychiatric condition show that group-counseling and interventions leading to empowerment of women have reported non-significant reduction in depression economic skill building: Mean Difference MD -7.53; 95% CI: -17.24, 2.18; counseling: MD-2.92; 95% CI: -13.17, 7.33.

ConclusionWhile prevention and management of the chronic diseases like diabetes and hypertension, through counseling, and other dietary and pharmacological intervention, is important, delivering solutions to prevent and respond to women’s psychological health problems are urgently needed to combat this leading cause of morbidity.

Keywordschronic disease diabetes hypertension preconception epilepsy Electronic supplementary materialThe online version of this article doi:10.1186-1742-4755-11-S3-S5 contains supplementary material, which is available to authorized users.

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Autor: Zohra S Lassi - Ayesha M Imam - Sohni V Dean - Zulfiqar A Bhutta


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