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Environmental Health

, 9:62

First Online: 18 October 2010Received: 27 July 2010Accepted: 18 October 2010DOI: 10.1186-1476-069X-9-62

Cite this article as: Cantonwine, D., Meeker, J.D., Hu, H. et al. Environ Health 2010 9: 62. doi:10.1186-1476-069X-9-62

Abstract

BackgroundPresence of Bisphenol A BPA has been documented worldwide in a variety of human biological samples. There is growing evidence that low level BPA exposure may impact placental tissue development and thyroid function in humans. The aim of this present pilot study was to determine urinary concentrations of BPA during the last trimester of pregnancy among a small subset of women in Mexico City, Mexico and relate these concentrations to risk of delivering prematurely.

MethodsA nested case-control subset of 60 participants in the Early Life Exposure in Mexico to ENvironmental Toxicants ELEMENT study in Mexico City, Mexico were selected based on delivering less than or equal to 37 weeks of gestation and greater than 37 weeks of gestation. Third trimester archived spot urine samples were analyzed by online solid phase extraction coupled with high performance liquid chromatography isotope dilution tandem mass spectrometry.

ResultsBPA was detected in 80.0% N = 48 of the urine samples; total concentrations ranged from < 0.4 μg-L to 6.7 μg-L; uncorrected geometric mean was 1.52 μg-L. The adjusted odds ratio of delivering less than or equal to 37 weeks in relation to specific gravity adjusted third trimester BPA concentration was 1.91 95%CI 0.93, 3.91, p-value = 0.08. When cases were further restricted to births occurring prior to the 37 week n = 12, the odds ratio for specific-gravity adjusted BPA was larger and statistically significant p < 0.05.

ConclusionsThis is the first study to document measurable levels of BPA in the urine of a population of Mexican women. This study also provides preliminary evidence, based on a single spot urine sample collected during the third trimester, that pregnant women who delivered less than or equal to 37 weeks of gestation and prematurely < 37 weeks had higher urinary concentrations of BPA compared to women delivering after 37 weeks.

List of AbbreviationsBPABisphenol A

ELEMENTEarly Life Exposure in Mexico to ENvironmental Toxicants

NHANESNational Health and Nutrition Examination Survey

CDCCenters for Disease Control and Prevention

SPEsolid-phase extraction

HPLChigh performance liquid chromatography

MS-MStandem mass spectrometry

Crcreatinine

LODlimit of detection

SGspecific gravity

Electronic supplementary materialThe online version of this article doi:10.1186-1476-069X-9-62 contains supplementary material, which is available to authorized users.

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Autor: David Cantonwine - John D Meeker - Howard Hu - Brisa N Sánchez - Héctor Lamadrid-Figueroa - Adriana Mercado-García - Ga

Fuente: https://link.springer.com/







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