Study protocol: a randomised controlled trial investigating the effect of exercise training on peripheral blood gene expression in patients with stable anginaReportar como inadecuado




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BMC Public Health

, 10:620

First Online: 18 October 2010Received: 01 September 2010Accepted: 18 October 2010DOI: 10.1186-1471-2458-10-620

Cite this article as: Bourke, L., Tew, G.A., Milo, M. et al. BMC Public Health 2010 10: 620. doi:10.1186-1471-2458-10-620

Abstract

BackgroundExercise training has been shown to reduce angina and promote collateral vessel development in patients with coronary artery disease. However, the mechanism whereby exercise exerts these beneficial effects is unclear. There has been increasing interest in the use of whole genome peripheral blood gene expression in a wide range of conditions to attempt to identify both novel mechanisms of disease and transcriptional biomarkers. This protocol describes a study in which we will assess the effect of a structured exercise programme on peripheral blood gene expression in patients with stable angina, and correlate this with changes in angina level, anxiety, depression, and exercise capacity.

Methods-DesignSixty patients with stable angina will be recruited and randomised 1:1 to exercise training or conventional care. Patients randomised to exercise training will attend an exercise physiology laboratory up to three times weekly for supervised aerobic interval training sessions of one hour in total duration. Patients will undergo assessments of angina, anxiety, depression, and peripheral blood gene expression at baseline, after six and twelve weeks of training, and twelve weeks after formal exercise training ceases.

DiscussionThis study will provide comprehensive data on the effect of exercise training on peripheral blood gene expression in patients with angina. By correlating this with improvement in angina status we will identify candidate peripheral blood transcriptional markers predictive of improvements in angina level in response to exercise training.

Trial RegistrationClinicaltrials.gov identifier: NCT01147952

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2458-10-620 contains supplementary material, which is available to authorized users.

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Autor: Liam Bourke - Garry A Tew - Marta Milo - David C Crossman - John M Saxton - Timothy JA Chico

Fuente: https://link.springer.com/







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