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Advances in Biology - Volume 2015 2015, Article ID 486510, 5 pages -

Research ArticleDepartment of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Okofia Nnewi Campus, Anambra State, Nigeria

Received 31 August 2015; Revised 2 October 2015; Accepted 7 October 2015

Academic Editor: Antimo Di Maro

Copyright © 2015 U. U. Ukoha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hibiscus sabdariffa L. has been used traditionally as herbal medicine and has been documented to have a broad range of therapeutic effects. The present study aimed to investigate the effects of chronic administration of aqueous extract of flowers of Hibiscus sabdariffa on the histology of the kidney and some biochemical indices of renal function in male Wistar rats. Twenty 20 Wistar rats were randomly divided into four 4 groups of five rats each. The extract was administered orally in doses 200, 500, and 800 mg-kg body weight for 21 days. The kidney was harvested and processed histologically and blood samples were taken for biochemical assays. The histological results showed dose dependent pathological states and the biochemical analysis revealed a dose dependant variation in renal indices. These results suggest that chronic administration of aqueous extract of Hibiscus sabdariffa may be toxic to the kidney.





Autor: U. U. Ukoha, S. I. Mbagwu, G. U. Ndukwe, and C. Obiagboso

Fuente: https://www.hindawi.com/



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