Comparative Efficacy and Toxicity of Different Species of Sargassum in Haizao Yuhu Decoction in PTU-Induced Goiter RatsReportar como inadecuado

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Evidence-Based Complementary and Alternative Medicine - Volume 2017 2017, Article ID 3526186, 10 pages -

Research ArticleBeijing University of Chinese Medicine, Beijing, China

Correspondence should be addressed to Gansheng Zhong

Received 18 November 2016; Accepted 18 May 2017; Published 21 June 2017

Academic Editor: Shruti Shukla

Copyright © 2017 Linlin Xiu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Haizao Yuhu Decoction has been widely used to treat thyroid-related diseases especially goiter with few side effects in traditional Chinese medicine TCM, including herb pair Sargassum HZ and Glycyrrhizae Radix et Rhizoma GC, as one of -eighteen antagonistic medicaments.- The two different species of Sargassum, Sargassum fusiforme Sf and Sargassum pallidum Sp, are not clearly differentiated in clinical use, so that herb pair Sf-GC and Sp-GC could show different effect and toxicity. Methods. We investigated the antigoitrous effect and toxicity and clarified the potential underlying mechanism of the two different species of Sargassum in HYD HYDf and HYDp in PTU-reduced goiter rats. Results. The results demonstrated that both HYDf and HYDp could exhibit antigoitrous effect through alterations in hypothalamus-pituitary-thyroid HPT axis and inhibition of the TPO gene expression; there is no difference in the antigoitrous effects between the two different species of Sargassum application in HYD. Conclusion. This study evaluated the safety and efficacy of herb pair HZ-GC applied in HYD in goiter rats at molecular, cellular, and whole level and compared the two species of Sargassum further. We provide a reliable way to clarify the possible mechanism of the antagonistic medicament herb pair HZ-GC for its application.

Autor: Linlin Xiu, Gansheng Zhong, Dianna Liu, Shaohong Chen, Haiyan Liu, and Feng Chen



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