The GRADE approach for assessing new technologies as applied to apheresis devices in ulcerative colitisReportar como inadecuado




The GRADE approach for assessing new technologies as applied to apheresis devices in ulcerative colitis - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Implementation Science

, 5:48

First Online: 16 June 2010Received: 27 May 2009Accepted: 16 June 2010DOI: 10.1186-1748-5908-5-48

Cite this article as: Ibargoyen-Roteta, N., Gutiérrez-Ibarluzea, I., Rico-Iturrioz, R. et al. Implementation Sci 2010 5: 48. doi:10.1186-1748-5908-5-48

Abstract

BackgroundIn the last few years, a new non-pharmacological treatment, termed apheresis, has been developed to lessen the burden of ulcerative colitis UC. Several methods can be used to establish treatment recommendations, but over the last decade an informal collaboration group of guideline developers, methodologists, and clinicians has developed a more sensible and transparent approach known as the Grading of Recommendations, Assessment, Development and Evaluation GRADE. GRADE has mainly been used in clinical practice guidelines and systematic reviews. The aim of the present study is to describe the use of this approach in the development of recommendations for a new health technology, and to analyse the strengths, weaknesses, opportunities, and threats found when doing so.

MethodsA systematic review of the use of apheresis for UC treatment was performed in June 2004 and updated in May 2008. Two related clinical questions were selected, the outcomes of interest defined, and the quality of the evidence assessed. Finally, the overall quality of each question was taken into account to formulate recommendations following the GRADE approach. To evaluate this experience, a SWOT strengths, weaknesses, opportunities and threats analysis was performed to enable a comparison with our previous experience with the SIGN Scottish Intercollegiate Guidelines Network method.

ResultsApplication of the GRADE approach allowed recommendations to be formulated and the method to be clarified and made more explicit and transparent. Two weak recommendations were proposed to answer to the formulated questions. Some challenges, such as the limited number of studies found for the new technology and the difficulties encountered when searching for the results for the selected outcomes, none of which are specific to GRADE, were identified. GRADE was considered to be a more time-consuming method, although it has the advantage of taking into account patient values when defining and grading the relevant outcomes, thereby avoiding any influence from literature precedents, which could be considered to be a strength of this method.

ConclusionsThe GRADE approach could be appropriate for making the recommendation development process for Health Technology Assessment HTA reports more explicit, especially with regard to new technologies.

Electronic supplementary materialThe online version of this article doi:10.1186-1748-5908-5-48 contains supplementary material, which is available to authorized users.

Iñaki Gutiérrez-Ibarluzea, Rosa Rico-Iturrioz, Marta López-Argumedo, Eva Reviriego-Rodrigo, Jose Luis Cabriada-Nuño and Holger J Schünemann contributed equally to this work.

Download fulltext PDF



Autor: Nora Ibargoyen-Roteta - Iñaki Gutiérrez-Ibarluzea - Rosa Rico-Iturrioz - Marta López-Argumedo - Eva Reviriego-Rodrigo - Jo

Fuente: https://link.springer.com/







Documentos relacionados