Subclinical hyperthyroidism and dementia: the Sao Paulo Ageing and Health Study SPAHReport as inadecuate




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BMC Public Health

, 10:298

First Online: 01 June 2010Received: 21 December 2009Accepted: 01 June 2010DOI: 10.1186-1471-2458-10-298

Cite this article as: Benseñor, I.M., Lotufo, P.A., Menezes, P.R. et al. BMC Public Health 2010 10: 298. doi:10.1186-1471-2458-10-298

Abstract

BackgroundSeveral epidemiologic studies have shown a possible association between thyroid function and cognitive decline. Our aim was to evaluate the association of subclinical hyperthyroidism and dementia in a population sample of older people

MethodsA cross-sectional study - São Paulo Ageing and Health Study SPAH - in a population sample of low-income elderly people ≥ 65 years-old to evaluate presence of subclinical thyroid disease as a risk factor for dementia. Thyroid function was assessed using thyrotropic hormone and free-thyroxine as well as routine use of thyroid hormones or antithyroid medications. Cases of dementia were assessed using a harmonized one-phase dementia diagnostic procedure by the -10-66 Dementia Research Group- including Alzheimer-s disease and vascular dementia. Logistic regression models were used to test a possible association between subclinical hyperthyroidism and dementia.

Results and discussionPrevalence of dementia and of subclinical hyperthyroidism were respectively of 4.4% and 3.0%. After age adjustment, we found an association of subclinical hyperthyroidism and any type of dementia and vascular dementia Odds Ratio, 4.1, 95% Confidence Interval 95% CI 1.3-13.1, and 5.3 95% CI, 1.1-26.4; respectively. Analyzing data by gender, we found an association of subclinical hyperthyroidism with dementia and Alzheimer-s disease only for men OR, 8.0; 95% CI, 1.5-43.4; OR, 12.4; 95% CI, 1.2-128.4; respectively. No women with subclinical hypothyroidism presented Alzheimer-s disease in the sample.

ConclusionThe results suggest a consistent association among people with subclinical hyperthyroidism and dementia.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2458-10-298 contains supplementary material, which is available to authorized users.

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Author: Isabela M Benseñor - Paulo A Lotufo - Paulo R Menezes - Márcia Scazufca

Source: https://link.springer.com/







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