Alloreactive Regulatory T Cells Allow the Generation of Mixed Chimerism and Transplant ToleranceReport as inadecuate




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The induction of donor-specific transplant tolerance is one of the main goals of modern immunology. Establishment of a mixed chimerism state in the transplant recipient has proven to be a suitable strategy for the induction of long-term allograft tolerance; however, current experimental recipient preconditioning protocols have many side effects, and are not feasible for use in future therapies. In order to improve the current mixed chimerism induction protocols, we developed a non-myeloablative bone-marrow transplant NM-BMT protocol using retinoic acid RA-induced alloantigen-specific Tregs, clinically available immunosuppressive drugs, and lower doses of irradiation. We demonstrate that RA-induced alloantigen-specific Tregs in addition to a NM-BMT protocol generates stable mixed chimerism and induces tolerance to allogeneic secondary skin allografts in mice. Therefore, the establishment of mixed chimerism through the use of donor-specific Tregs rather than non-specific immunosuppression could have a potential use in organ transplantation.Nota general

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Author: Ruiz, Paulina; - Maldonado, Paula; - Hidalgo, Yessia; - Sauma Mahaluf, Daniela Macarena; - Rosemblatt Silber, Mario Cesar; - Bono

Source: http://repositorio.uchile.cl/



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