Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin ResistanceReport as inadecuate




Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance - Download this document for free, or read online. Document in PDF available to download.

Mediators of Inflammation - Volume 2016 2016, Article ID 3085390, 9 pages -

Research Article

Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950 Colonia Independencia, CP 44340, Guadalajara, JAL, Mexico

Instituto de Investigación en Reumatología y del Sistema Musculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950 Colonia Independencia, CP 44340, Guadalajara, JAL, Mexico

UDG-CA-701, Grupo de Investigación Inmunometabolismo en Enfermedades Emergentes GIIEE, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950 Colonia Independencia, CP 44340, Guadalajara, JAL, Mexico

Departamento de Farmacobiología, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Boulevard Marcelino García Barragán No. 1421, CP 44430, Guadalajara, JAL, Mexico

Departamento de Disciplinas Filosófico, Metodológico e Instrumentales, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950 Colonia Independencia, CP 44340, Guadalajara, JAL, Mexico

UDG-CA-703, Grupo de Investigación en Inmunología y Reumatología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950 Colonia Independencia, CP 44340, Guadalajara, JAL, Mexico

Translational Cardiology, Centre for Molecular Medicine, Department of Medicine, Karolinska Institutet, L8:03, 17176 Stockholm, Sweden

Servicio de Reumatología, División de Medicina Interna, Hospital Civil -Dr. Juan I. Menchaca-, Universidad de Guadalajara, Salvador de Quevedo y Zubieta No. 750, CP 44340, Guadalajara, JAL, Mexico

Received 10 February 2016; Accepted 10 April 2016

Academic Editor: Jose C. Rosa

Copyright © 2016 Fernanda-Isadora Corona-Meraz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. In obesity there is a subclinical chronic low-grade inflammatory response where insulin resistance IR may develop. Chemerin is secreted in white adipose tissue and promotes low-grade inflammatory process, where it expressed CMKLR1 receptor. The role of chemerin and CMKLR1 in inflammatory process secondary to obesity is not defined yet. Methods. Cross-sectional study with 134 individuals classified as with and without obesity by body mass index BMI and IR. Body fat storage measurements and metabolic and inflammatory markers were measured by routine methods. Soluble chemerin and basal levels of insulin by ELISA and relative expression of CMKLR1 were evaluated with qPCR and method. Results. Differences were observed between obesity and lean individuals in body fat storage measurements and metabolic-inflammatory markers. Both CMKLR1 expression and chemerin levels were increased in obesity without IR. Soluble chemerin levels correlate with adiposity and metabolic markers % to 38.5%, . Conclusion. The increment of CMKLR1 expression was associated with insulin production. Increased serum levels of chemerin in obesity were observed, favoring a dysmetabolic response. The results observed in this study suggest that both chemerin and CMKLR1 have opposite expression in the context of low-grade inflammatory response manifested in the development of IR.





Author: Fernanda-Isadora Corona-Meraz, Rosa-Elena Navarro-Hernández, Sandra-Luz Ruíz-Quezada, Perla-Monserrat Madrigal-Ruíz, Jorge

Source: https://www.hindawi.com/



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