Hematological and hepatic alterations in nonsmoking residents exposed to benzene following a flaring incident at the British petroleum plant in Texas CityReport as inadecuate




Hematological and hepatic alterations in nonsmoking residents exposed to benzene following a flaring incident at the British petroleum plant in Texas City - Download this document for free, or read online. Document in PDF available to download.

Environmental Health

, 13:115

First Online: 20 December 2014Received: 14 August 2014Accepted: 05 November 2014DOI: 10.1186-1476-069X-13-115

Cite this article as: D’Andrea, M.A. & Reddy, G.K. Environ Health 2014 13: 115. doi:10.1186-1476-069X-13-115

Abstract

ObjectiveHuman exposure to benzene is associated with multiple adverse health effects with an increased risk of developing carcinogenesis. Benzene exposure is known to affect many critical organs including the hematological, hepatic, renal, lung, and cardiac functions. The purpose of this study is to examine the health effects of benzene exposure among nonsmoking subjects from a prolonged flaring incident that occurred at the British petroleum BP refinery in the Texas City, Texas.

MethodsThe study included nonsmoking subjects who had been exposed and unexposed to benzene. Using medical charts, clinical data including white blood cell WBC counts, platelet counts, hemoglobin, hematocrit, blood urea nitrogen BUN, creatinine, alkaline phosphatase ALP, aspartate amino transferase AST, and alanine amino transferase ALT in nonsmoking subjects exposed to benzene were reviewed and analyzed and compared with unexposed adults.

ResultsA total of 1422 nonsmoking subjects benzene exposed, n = 1093 and unexposed, n = 329 were included. Benzene exposed subjects had significantly higher levels of WBC × 10 per μL counts 7.7 ± 2.2 versus 6.8 ± 1.7, P = 0.001 and platelet × 10 per μL counts 288.8 ± 59.0 versus 245.3 ± 54.4, P = 0.001 compared with the unexposed subjects. The mean serum creatinine mg-dL levels were also significantly increased in the benzene exposed group compared with the unexposed group 1.1 ± 0.4 versus 0.8 ± 0.2, P = 0.001. Serum levels of ALP IU-L was significantly elevated in the benzene exposed subjects compared with the unexposed subjects 87.3 ± 22.6 versus 69.6 ± 16.5, P = 0.001. Similarly, benzene exposed subjects had significantly higher levels of AST and ALT compared with those unexposed subjects.

ConclusionBenzene exposure from the prolonged BP flaring incident caused significant alterations in hematological and liver markers indicating that these nonsmoking residents exposed to refinery chemicals may be at a higher risk of developing hepatic or blood related disorders.

KeywordsBenzene poisoning Blood disorders Chemical exposure Health impact Hematological toxicity Hepatotoxicity Nonsmoking Petroleum refinery Electronic supplementary materialThe online version of this article doi:10.1186-1476-069X-13-115 contains supplementary material, which is available to authorized users.

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Author: Mark A D’Andrea - G Kesava Reddy

Source: https://link.springer.com/







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