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BioMed Research International - Volume 2015 2015, Article ID 280891, 5 pages -

Research Article

Hygiene and Public Health, Department of G.F. Ingrassia, University of Catania, Via Santa Sofia 87, 95123 Catania, Italy

Occupational Medicine, Department of Clinical and Molecular Science, Polytechnic University of Marche, Via Tronto 10-A, 60100 Ancona, Italy

Division of Clinical Pathology, Hospital of Taormina, ASP Messina, C-da Sirina, 98039 Taormina, Italy

Division of Cardiology, Hospital of Lentini, ASP Siracusa, C-da Colle Roggio, 96016 Lentini, Italy

Occupational Medicine -Policlinico-Vittorio Emanuele- University Hospital, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy

Received 18 November 2014; Revised 22 January 2015; Accepted 27 May 2015

Academic Editor: Sunil Kumar

Copyright © 2015 Caterina Ledda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hypertension is the most common medical problem encountered during pregnancy, complicating 2-3% of pregnancies. High blood pressure BP with diastolic BP ≥ 90 mm Hg and-or systolic BP ≥ 140 mm Hg arising after week 22 of pregnancy and resolving after delivery is defined as gestational hypertension GHY. The aim of this cross-sectional study was to investigate whether occupational and-or environmental exposure to organophosphorus OP pesticide affects GHY. Women at approximately 22 weeks of gestation were recruited. OP pesticide exposure in the first trimester of pregnancy was classified into four categories: no exposure, indirect exposure, domestic exposure, and occupational exposure. Application of the exclusion criteria left 2203 participants mean age 30.4 ± 11.6 years. Data analysis showed that in women with indirect OP pesticide exposure the incidence of GHY was slightly higher than that in the world population, whereas domestic exposure involved a 7% increase and occupational exposure a 12% increase. Analysis of the pesticides used by participants highlighted a possible role for malathion and diazinon adjusted OR 1.09 and 1.14, resp

Further investigation of exposed workers and the general population is clearly warranted given the broad diffusion of OP pesticides and their possible public health impact, maybe by including a wider range of health outcomes.

Author: Caterina Ledda, Maria Fiore, Lory Santarelli, Massimo Bracci, Giuseppe Mascali, Maria Grazia D’Agati, Alfredo Busà, Marg



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