Immunohistochemical Markers as Predictors of Histopathologic Response and Prognosis in Rectal Cancer Treated with Preoperative Adjuvant Therapy: State of the ArtReport as inadecuate




Immunohistochemical Markers as Predictors of Histopathologic Response and Prognosis in Rectal Cancer Treated with Preoperative Adjuvant Therapy: State of the Art - Download this document for free, or read online. Document in PDF available to download.

Gastroenterology Research and Practice - Volume 2017 2017, Article ID 2808235, 6 pages - https:-doi.org-10.1155-2017-2808235

Review Article

Division of Pathology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan, Via Francesco Sforza 25, 20122 Milan, Italy

Department of Biomedical, Surgical and Dental Sciences, University of Milan Medical School, Via Francesco Sforza 35, 20122 Milan, Italy

Correspondence should be addressed to Stefano Ferrero

Received 5 September 2016; Accepted 23 January 2017; Published 23 February 2017

Academic Editor: Giovanni Blandino

Copyright © 2017 Alessandro Del Gobbo and Stefano Ferrero. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We explain the state of the art of the immunohistochemical markers of response in rectal cancers treated with neoadjuvant medical therapies and its implication with prognosis. Neoadjuvant chemoradiotherapy is widely used to improve the outcome of patients with locally advanced rectal cancer, and the evaluation of the effects of medical therapy is to date based on histomorphological examination by applying four grading systems of response to therapy tumor regression grade TRG. The need to identify immunohistochemical markers that could ensure a better assessment of response and possibly provide additional prognostic information has emerged. We identified p53, p27kip1, Ki67, matrix metalloprotease-9, survivin, Ki67 proliferative index, CD133, COX2, CD44v6, thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase as the most common markers studied in literature to date, and we explained their prognostic potential and their implications in the evaluation of the response to preoperative therapies in rectal cancers.





Author: Alessandro Del Gobbo and Stefano Ferrero

Source: https://www.hindawi.com/



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