Genotoxicity of Anesthetics Evaluated In Vivo AnimalsReport as inadecuate

Genotoxicity of Anesthetics Evaluated In Vivo Animals - Download this document for free, or read online. Document in PDF available to download.

BioMed Research International - Volume 2015 2015, Article ID 280802, 8 pages -

Review Article

Faculdade de Medicina de Botucatu, UNESP-Univ Estadual Paulista, Departamento de Anestesiologia, Distrito de Rubiao Junior, s-n, 18618-970 Botucatu, SP, Brazil

Toxicology Department, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey

Received 23 January 2015; Accepted 28 May 2015

Academic Editor: Annette Rebel

Copyright © 2015 Mariana G. Braz and Bensu Karahalil. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The anesthesia has been improved all over the years. However, it can have impact on health, in both patients and animals anesthetized, as well as professionals exposed to inhaled anesthetics. There is continuing effort to understand the possible effects of anesthetics at molecular levels. Knowing the effects of anesthetic agents on genetic material could be a valuable basic support to better understand the possible mechanisms of these agents. Thus, the purpose of this review is to provide an overview on the genotoxic potential, evaluated in animal models, of many anesthetics that have already been used and those currently used in anesthesia.

Author: Mariana G. Braz and Bensu Karahalil



Related documents