Host Cell Phenotypic Variability Induced by Trypanosomatid-Parasite-Released Immunomodulatory Factors: Physiopathological ImplicationsReport as inadecuate




Host Cell Phenotypic Variability Induced by Trypanosomatid-Parasite-Released Immunomodulatory Factors: Physiopathological Implications - Download this document for free, or read online. Document in PDF available to download.

Journal of Biomedicine and Biotechnology - Volume 2004 2004, Issue 3, Pages 167-174

Review article

Institut de la Recherche pour le Développement, Unité de Recherche no 008 -Pathogénie des Trypanosomatidae-, Montpellier, France

Service de Chirurgie Digestive et Générale, Hôpital Sainte Marguerite, 270 Boulevard de Sainte Marguerite, Marseille, France

Biochemical Laboratory, Faculty of Pharmacy, University of Porto, Portugal

Institute of Molecular and Cellular Biology, University of Porto, Portugal

Received 6 November 2003; Revised 27 January 2004; Accepted 11 February 2004

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The parasitic protozoa Trypanosoma cruzi and Leishmania sp release a variety of molecules into their mammalian hosts ESA: excretory-secretory products. The effects of these ESA on the host cell function may participate in the establishment of a successful infection, in which the parasite persists for a sufficient period of time to complete its life cycle. A number of regulatory components or processes originating from the parasite that control or regulate the metabolism and the growth of host cell have been identified. The purpose of the present review is to analyze some of the current data related to the parasite ESA that interfere with the host cell physiology. Special attention is given to members of conserved protein families demonstrating remarkable diversity and plasticity of function ie, glutathione S-transferases and related molecules; members of the trans-sialidase and mucin family; and members of the ribosomal protein family. The identification of parasite target molecules and the elucidation of their mode of action toward the host cell represents a step forward in efforts aimed at an immunotherapeutic or pharmacological control of parasitic infection.





Author: Ali Ouaissi, Mehdi Ouaissi, Joana Tavares, and Anabela Cordeiro-Da-Silva

Source: https://www.hindawi.com/



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