Preparation and Characterization of Modified Polyethyleneimine Magnetic Nanoparticles for Cancer Drug DeliveryReport as inadecuate




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Journal of Nanomaterials - Volume 2016 2016, Article ID 2806407, 6 pages -

Research Article

Department of Chemistry, Faculty of Sciences, Islamic Azad University, Arak Branch, Arak, Iran

Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14176, Iran

Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14176, Iran

Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14176, Iran

Received 21 January 2016; Accepted 10 April 2016

Academic Editor: Zhiguang Wang

Copyright © 2016 Sedighe Arabi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Magnetic nanoparticles with polymeric coating have great significance in drug delivery purpose. We intended to prepare a modified amphiphilic polymer with targeting susceptibility to reduce side effects to normal cells. In this study polyethyleneimine PEI as a polycationic polymer reacted with sebacoyl chloride to make a new amphiphilic polymer and folic acid as a targeting agent to reduce cytotoxicity of polymer and increase specific entrance of nanoparticles to cancerous cells. The obtained polymer PEI-Sb-FA was then coated on magnetic nanoparticles MNPs to stabilize them. The core-shell nanoparticles were characterized by different methods such as scanning electron microscopy SEM, X-ray diffraction XRD, thermogravimetric analysis TGA, and vibrating sample magnetometer VSM. Curcumin was finally loaded on PEI-Sb-FA-MNPs and the release behavior was studied in different pH. Curcumin loading of 28.2% was obtained and released drug in acidic pH = 4.5 was more than pH = 7.4, showing drug release sensitivity toward pH of media.





Author: Sedighe Arabi, Hamid Akbari Javar, and Mehdi Khoobi

Source: https://www.hindawi.com/



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