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BMC Health Services Research

, 10:105

First Online: 27 April 2010Received: 08 January 2010Accepted: 27 April 2010DOI: 10.1186-1472-6963-10-105

Cite this article as: Gray, A.M. & Papanicolas, I.N. BMC Health Serv Res 2010 10: 105. doi:10.1186-1472-6963-10-105

Abstract

BackgroundCoeliac disease is a common chronic autoimmune disorder. Underdiagnosis is common and the quality of life impact of symptoms may be severe. We report a study of symptom duration and quality of life before and after diagnosis in a representative sample of people with diagnosed coeliac disease in the UK.

MethodsPostal questionnaire of 2000 people with diagnosed coeliac disease, requesting information on date of diagnosis, type and duration of symptoms, and quality of life before and after diagnosis using the EQ-5D instrument.

ResultsThe survey response rate was 40% 788-2000. Mean duration of symptoms prior to diagnosis was 13.2 years, with some evidence of shorter duration in recent years. Respondents reported a mean of 13 consultations with their GP about their symptoms prior to diagnosis. The mean utility value of pre-diagnosis quality of life was 0.56, compared to 0.84 at time of survey, a highly statistically significant improvement of 0.27 95% c.i. 0.25, 0.30.

ConclusionsThe symptoms of undiagnosed coeliac disease are associated with a prolonged and substantial decrement to quality of life. These results strengthen the case for detailed examination of the cost-effectiveness of improved methods of detection and diagnosis, including population screening.

Electronic supplementary materialThe online version of this article doi:10.1186-1472-6963-10-105 contains supplementary material, which is available to authorized users.

Alastair M Gray and Irene N Papanicolas contributed equally to this work.

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Author: Alastair M Gray - Irene N Papanicolas

Source: https://link.springer.com/







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