Effects of Early Training and Nicotine Treatment on the Performance of Male NMRI Mice in the Water MazeReportar como inadecuado

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Neural Plasticity - Volume 10 2003, Issue 4, Pages 303-317

Departament de Psicologia, Facultat de Ciències de l-Educació i Psicologia, Universitat Rovira i Virgili, Carretera de Valls s-n, Tarragona 43007, Spain

Área de Psicobiologia, Facultad de Psicologia, Universitat de València, Avda Blasco Ibáñz, 21, Valencia 46010, Spain

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This research aimed to evaluate the effect ofnicotine treatment and prior training on aspatial learning task in differently aged NMRImale mice. In a longitudinal study, mice wererandomly assigned to one of 14 experimentalgroups receiving different combinations ofchronically injected nicotine 0.35 mg-kgadministered for 10 days 5 days before andduring 5 days acquisition of task or controltreatments and training in the water maze atdifferent ages. The mice displayed shorterescape latencies when evaluated at 6 and 10months than when tested in this task at 2months for the first time, demonstrating thatearly training preserves performance in thewater maze up to 8 months after the initialexperience. Nicotine treatment did notsignificantly change performance in the watermaze at any age tested. Early practice in aspatial reference memory task appears to havelasting consequences and can potentiallycontribute to preventing some age-relatedspatial learning deficits.

Autor: Paloma Vicens, M. Carmen Carrasco, and Rosa Redolat

Fuente: https://www.hindawi.com/


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