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European Journal of Epidemiology

, Volume 30, Issue 6, pp 501–508

First Online: 18 March 2015Received: 26 October 2014Accepted: 10 March 2015DOI: 10.1007-s10654-015-0018-5

Cite this article as: Engeland, A., Bjørge, T., Klungsøyr, K. et al. Eur J Epidemiol 2015 30: 501. doi:10.1007-s10654-015-0018-5


We explored the association between preeclampsia and later use of antihypertensive drugs in a population-based study with data from the Medical Birth Registry of Norway and the Norwegian Prescription Database. The study cohort consisted of 980,000 women having 2.1 million pregnancies during 1967–2012. Hazard ratios HRs with 95 % confidence intervals 95 % CI were estimated in multivariate time-dependent Cox proportional hazards regression models. Overall, the HR of later use of antihypertensive drugs was 2.0 95 % CI 2.0–2.0 in women with one preeclamptic pregnancy compared to women without preeclamptic pregnancies. The HR increased by increasing number of preeclamptic pregnancies, both term and preterm pregnancies. In women with two or more preeclamptic pregnancies, the HR was 2.8 2.7–3.0. The overall HR after 40 years of follow-up for women with one preeclamptic pregnancy was 1.3 1.2–1.4 and for two or more preeclamptic pregnancies the HR was 1.6 1.1–2.1. The first 5 years after the first birth, the HR of being dispensed antihypertensive drugs was higher in preterm 8.4 7.7–9.1 than term preeclamptic pregnancies 4.34.0–4.6. However, after 10 years, this difference was no longer present. The HR of later use of antihypertensive drugs increased with the number of preeclamptic pregnancies, and in the first 10 years the HR was higher after a preterm than a term preeclamptic pregnancy. Although the HR decreased with time since first birth, the risk was still elevated after 40 years.

KeywordsPreeclampsia Antihypertensive drugs Prescriptions Population-based registries AbbreviationsATCAnatomical Therapeutic Chemical

CIConfidence interval

HRHazard ratio

ICDInternational Classification of Diseases

MBRNMedical Birth Registry of Norway

NorPDNorwegian Prescription Database


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Autor: Anders Engeland - Tone Bjørge - Kari Klungsøyr - Rolv Skjærven - Svetlana Skurtveit - Kari Furu


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