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Cellular and Molecular Life Sciences

, Volume 67, Issue 19, pp 3255–3273

First Online: 12 June 2010Received: 19 March 2010Revised: 18 May 2010Accepted: 19 May 2010DOI: 10.1007-s00018-010-0414-7

Cite this article as: Jordan, S.D., Könner, A.C. & Brüning, J.C. Cell. Mol. Life Sci. 2010 67: 3255. doi:10.1007-s00018-010-0414-7


The central nervous system CNS is capable of gathering information on the body’s nutritional state and it implements appropriate behavioral and metabolic responses to changes in fuel availability. This feedback signaling of peripheral tissues ensures the maintenance of energy homeostasis. The hypothalamus is a primary site of convergence and integration for these nutrient-related feedback signals, which include central and peripheral neuronal inputs as well as hormonal signals. Increasing evidence indicates that glucose and lipids are detected by specialized fuel-sensing neurons that are integrated in these hypothalamic neuronal circuits. The purpose of this review is to outline the current understanding of fuel-sensing mechanisms in the hypothalamus, to integrate the recent findings in this field, and to address the potential role of dysregulation in these pathways in the development of obesity and type 2 diabetes mellitus.

KeywordsHypothalamus Glucose Fatty acids Metabolism Energy homeostasis Obesity Type 2 diabetes mellitus  Download fulltext PDF

Autor: Sabine D. Jordan - A. Christine Könner - Jens C. Brüning


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