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Journal of Comparative Physiology B

, Volume 180, Issue 7, pp 1057–1065

First Online: 22 May 2010Received: 13 October 2009Revised: 19 April 2010Accepted: 23 April 2010DOI: 10.1007-s00360-010-0473-y

Cite this article as: Crossley, D.A., Jonker, S.S., Hicks, J.W. et al. J Comp Physiol B 2010 180: 1057. doi:10.1007-s00360-010-0473-y

Abstract

Angiotensin II Ang II is an important regulator of cardiovascular function in adult vertebrates. Although its role in regulating the adult system has been extensively investigated, the cardiovascular response to Ang II in embryonic vertebrates is relatively unknown. We investigated the potential of Ang II as a regulator of cardiovascular function in embryonic chickens, which lack central nervous system control of cardiovascular function throughout the majority of incubation. The cardiovascular response to Ang II in embryonic chickens was investigated over the final 50% of their development. Ang II produced a dose-dependent increase in arterial pressure on each day of development studied, and the response increased in intensity as development progressed. The Ang II type-1 receptor nonspecific competitive peptide antagonist Sar ile Ang II blocked the cardiovascular response to subsequent injections of Ang II on day 21 only. The embryonic pressure response to Ang II hypertension only differed from that of adult chickens, in which initial hypotension is followed by hypertension. The constant level of gene expression for the Ang II receptor, in conjunction with an increasing pressure response to the peptide, suggests that two Ang II receptor subtypes are present during chicken development. Collectively, the data indicate that Ang II plays an important role in the cardiovascular development of chickens; however, its role in maintaining basal function requires further study.

KeywordsVertebrates Pharmacology Development Physiology Communicated by H. V. Carey.

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Autor: Dane A. CrossleyII - Sonnet S. Jonker - James W. Hicks - Kent L. Thornburg

Fuente: https://link.springer.com/







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