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Cellular and Molecular Life Sciences

, Volume 67, Issue 19, pp 3219–3240

First Online: 18 June 2010Received: 23 December 2009Revised: 21 April 2010Accepted: 14 May 2010DOI: 10.1007-s00018-010-0419-2

Cite this article as: Le Dévédec, S.E., Yan, K., de Bont, H. et al. Cell. Mol. Life Sci. 2010 67: 3219. doi:10.1007-s00018-010-0419-2


Cell migration is essential in a number of processes, including wound healing, angiogenesis and cancer metastasis. Especially, invasion of cancer cells in the surrounding tissue is a crucial step that requires increased cell motility. Cell migration is a well-orchestrated process that involves the continuous formation and disassembly of matrix adhesions. Those structural anchor points interact with the extra-cellular matrix and also participate in adhesion-dependent signalling. Although these processes are essential for cancer metastasis, little is known about the molecular mechanisms that regulate adhesion dynamics during tumour cell migration. In this review, we provide an overview of recent advanced imaging strategies together with quantitative image analysis that can be implemented to understand the dynamics of matrix adhesions and its molecular components in relation to tumour cell migration. This dynamic cell imaging together with multiparametric image analysis will help in understanding the molecular mechanisms that define cancer cell migration.

KeywordsCancer Cell migration Matrix adhesions Dynamic imaging Multiparametric analysis  Download fulltext PDF

Autor: Sylvia E. Le Dévédec - Kuan Yan - Hans de Bont - Veerander Ghotra - Hoa Truong - Erik H. Danen - Fons Verbeek - Bob v


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