Fibrin Gel as an Injectable Biodegradable Scaffold and Cell Carrier for Tissue EngineeringReportar como inadecuado

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The Scientific World Journal - Volume 2015 2015, Article ID 685690, 10 pages -

Review ArticleDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA

Received 26 December 2014; Accepted 27 February 2015

Academic Editor: Raju Adhikari

Copyright © 2015 Yuting Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Due to the increasing needs for organ transplantation and a universal shortage of donated tissues, tissue engineering emerges as a useful approach to engineer functional tissues. Although different synthetic materials have been used to fabricate tissue engineering scaffolds, they have many limitations such as the biocompatibility concerns, the inability to support cell attachment, and undesirable degradation rate. Fibrin gel, a biopolymeric material, provides numerous advantages over synthetic materials in functioning as a tissue engineering scaffold and a cell carrier. Fibrin gel exhibits excellent biocompatibility, promotes cell attachment, and can degrade in a controllable manner. Additionally, fibrin gel mimics the natural blood-clotting process and self-assembles into a polymer network. The ability for fibrin to cure in situ has been exploited to develop injectable scaffolds for the repair of damaged cardiac and cartilage tissues. Additionally, fibrin gel has been utilized as a cell carrier to protect cells from the forces during the application and cell delivery processes while enhancing the cell viability and tissue regeneration. Here, we review the recent advancement in developing fibrin-based biomaterials for the development of injectable tissue engineering scaffold and cell carriers.

Autor: Yuting Li, Hao Meng, Yuan Liu, and Bruce P. Lee



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