Velocity Variation Assessment of Red Blood Cell Aggregation with Spectral Domain Doppler Optical Coherence TomographyReportar como inadecuado




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Annals of Biomedical Engineering

, Volume 38, Issue 10, pp 3210–3217

First Online: 15 May 2010Received: 05 January 2010Accepted: 05 May 2010DOI: 10.1007-s10439-010-0066-7

Cite this article as: Xu, X., Yu, L. & Chen, Z. Ann Biomed Eng 2010 38: 3210. doi:10.1007-s10439-010-0066-7

Abstract

We propose spectral domain Doppler optical coherence tomography SD-D-OCT to qualitatively measure red blood cell aggregation. Variance-standard deviation SD of the Doppler frequency spectrum in Doppler variance imaging of flowing blood under shearing conditions was developed as a new aggregation index. In in vitro microchannel-flow experiments, porcine blood at various hematocrits with aggregation characteristics induced by dextran 500 or at the presence of plasma fibrinogen was measured by a SD-D-OCT system with a spectrum centered at 1310 nm. The effects of shear rate, hematocrit, aggregation level on the SD values were investigated. The results demonstrate that Doppler variance imaging using the SD value was capable of differentiating the normal and the aggregated blood with hematocrits of 30–55% flowing at a shear rate of 40–60 s. The SD value was found to be nonsignificant hematocrit-dependent. It is also a sensitive and repeatable aggregation index for comparison between nonaggregated and aggregated blood samples.

KeywordsDoppler optical coherence tomography Doppler variance image Red blood cell aggregation Velocity variation Associate Editor Jing Bai oversaw the review of this article.

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Autor: Xiangqun Xu - Lingfeng Yu - Zhongping Chen

Fuente: https://link.springer.com/







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