The Relationship between Carotid Atherosclerosis, Inflammatory Cytokines, and Oxidative Stress in Middle-Aged and Elderly Hemodialysis PatientsReportar como inadecuado




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International Journal of NephrologyVolume 2013 2013, Article ID 835465, 5 pages

Clinical Study

Department of Nephrology, Huaihai Hospital of Xuzhou Medical College, 226 Tongsan Road, Xuzhou 221004, China

Department of Special Diagnosis, Huaihai Hospital of Xuzhou Medical College, 226 Tongsan Road, Xuzhou 221004, China

Clinical Laboratory, Huaihai Hospital of Xuzhou Medical College, 226 Tongsan Road, Xuzhou 221004, China

Received 29 April 2013; Revised 27 August 2013; Accepted 2 September 2013

Academic Editor: Alejandro Martín-Malo

Copyright © 2013 Hongqi Ren et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To identify the relationship between microinflammation, oxidative stress, and carotid arterial stiffness in hemodialysis patients. Methods. The CAS β and PWV obtained by ultrasound technology were used to assess carotid arterial stiffness. We divided the patients into either the CAS group or the non-CAS group based on the presence or absence of CAS. The parameters of ALB, Ca, P, TC, HDL, LDL, TG, glucose, creatinine, and hs-CRP levels were routinely tested in both groups of patients. The levels of TNF-α, IL-6, and 8-isoprostane F2α were measured by ELISA. Results. A total of 42 patients were enrolled in the CAS group and 20 patients were enrolled in the non-CAS group. No significant differences between the CAS group and the non-CAS group were observed with respect to age, dialysis duration, DBP, BUN, Cr, TC, TG, HDL, LDL, and Hb. However, SBP , pulse pressure, and 8-isoprostane levels of the CAS group were higher than those of the non-CAS group. The hs-CRP, TNF-α, and IL-6 levels were elevated in both groups but showed no significant differences. Conclusions. Maintenance of hemodialysis patients exhibits a microinflammatory state that may lead to atherosclerosis. The roles of hypertension and oxidative stress may be more important.





Autor: Hongqi Ren, Xuan Zhou, Zhiyong Luan, Xiaomei Luo, Shujing Han, Qing Cai, Wang Rui, and Yan Li

Fuente: https://www.hindawi.com/



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