A novel approach to modelling water transport and drug diffusion through the stratum corneumReportar como inadecuado




A novel approach to modelling water transport and drug diffusion through the stratum corneum - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Theoretical Biology and Medical Modelling

, 7:33

First Online: 17 August 2010Received: 17 June 2010Accepted: 17 August 2010DOI: 10.1186-1742-4682-7-33

Cite this article as: Marquez-Lago, T.T., Allen, D.M. & Thewalt, J. Theor Biol Med Model 2010 7: 33. doi:10.1186-1742-4682-7-33

Abstract

BackgroundThe potential of using skin as an alternative path for systemically administering active drugs has attracted considerable interest, since the creation of novel drugs capable of diffusing through the skin would provide a great step towards easily applicable -and more humane- therapeutic solutions. However, for drugs to be able to diffuse, they necessarily have to cross a permeability barrier: the stratum corneum SC, the uppermost set of skin layers. The precise mechanism by which drugs penetrate the skin is generally thought to be diffusion of molecules through this set of layers following a -tortuous pathway- around corneocytes, i.e. impermeable dead cells.

ResultsIn this work, we simulate water transport and drug diffusion using a three-dimensional porous media model. Our numerical simulations show that diffusion takes place through the SC regardless of the direction and magnitude of the fluid pressure gradient, while the magnitude of the concentrations calculated are consistent with experimental studies.

ConclusionsOur results support the possibility for designing arbitrary drugs capable of diffusing through the skin, the time-delivery of which is solely restricted by their diffusion and solubility properties.

Electronic supplementary materialThe online version of this article doi:10.1186-1742-4682-7-33 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Autor: Tatiana T Marquez-Lago - Diana M Allen - Jenifer Thewalt

Fuente: https://link.springer.com/







Documentos relacionados