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Autoimmune Diseases - Volume 2016 2016, Article ID 7529078, 5 pages -

Research Article

Department of Microbiology and Immunology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran

Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran

Razi Hospital, Tehran University of Medical Sciences, Tehran 11996 63911, Iran

Department of Statistics, Health Faculty, Kashan University of Medical Sciences, Kashan, Iran

Received 27 February 2016; Accepted 25 May 2016

Academic Editor: Alexander Szalai

Copyright © 2016 Zeinab Fagheei Aghmiyuni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pemphigus vulgaris are autoimmune blistering diseases that may result in significant morbidity and death. Immunosuppressive therapy of pemphigus vulgaris would predispose the patients to infections. The aim of this study was to assess the prevalence of S. aureus infection and PVL gene in patients with pemphigus admitted to dermatology clinic. Materials and Methods. This descriptive study was conducted on 196 pemphigus vulgaris patients 119 males, 77 females admitted to dermatology clinic between 2014 and 2015. In this study, the diagnosis of pemphigus vulgaris was made by histology, immunofluorescence pattern of perilesional skin, and indirect immunofluorescence testing of serum. Data were collected through a questionnaire. Results. 59.1% of pemphigus vulgaris patients had S. aureus infection. 49 out of 116 were methicillin-resistant. PVL gene was detected in 25 out of 116 S. aureus positive patients. Conclusion. This is the first report of S. aureus infection in pemphigus patients in Iran. More than forty percent of isolates were methicillin-resistant S. aureus. PVL gene carried by methicillin-resistant S. aureus was high in this study.

Author: Zeinab Fagheei Aghmiyuni, Ahmad Khorshidi, Rezvan Moniri, Tahereh Soori, and Seyed Gholam Abbas Musavi



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