The Ethanol Extract of the Inner Bark of Caesalpinia pyramidalis Tul. Reduces Urinary Bladder Damage during Cyclophosphamide-Induced Cystitis in RatsReportar como inadecuado




The Ethanol Extract of the Inner Bark of Caesalpinia pyramidalis Tul. Reduces Urinary Bladder Damage during Cyclophosphamide-Induced Cystitis in Rats - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

The Scientific World JournalVolume 2013 2013, Article ID 694010, 8 pages

Research Article

Department of Physiology, Federal University of Sergipe UFS, 49100-000 São Cristóvão, SE, Brazil

Department of Medicine, Federal University of Sergipe UFS, 49060-000 Aracaju, SE, Brazil

Department of Morphology, Federal University of Sergipe UFS, 49100-000 São Cristóvão, SE, Brazil

Received 11 August 2013; Accepted 29 September 2013

Academic Editors: F. Manzo and S. Mutalik

Copyright © 2013 Janaína P. Moraes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hemorrhagic cystitis HC is a common side effect of cyclophosphamide therapy, which deserves new therapeutic strategies, such as those based on natural products. The ethanol extract of the inner bark of Caesalpinia pyramidalis Tul. EECp possesses anti-inflammatory, antinociceptive, and antioxidant activities as previously showed by our group. We have investigated the effect of EECp on the cyclophosphamide-induced HC. Cystitis was induced in male Wistar rats by the injection of cyclophosphamide. These animals were pretreated with EECp 100–400 mg-kg, vehicle, or mesna. Myeloperoxidase activity and malondialdehyde formation were measured in urinary bladder and other tissues. Bladder edema and histopathological alterations and serum nitric oxide metabolites concentration were also evaluated. Treatment with EECp 100–400 mg-kg or mesna impaired the increase of myeloperoxidase activity in urinary bladder and the serum induced by cyclophosphamide but did not reduce edema in this tissue, as did mesna. Total histological score was reduced by EECp 100 mg-kg. Lung myeloperoxidase activity, which was increased by cyclophosphamide, was decreased significantly by EECp 400 mg-kg. EECp also diminished the malondialdehyde formation in bladder, lung, and spleen, although these parameters were not affected by cyclophosphamide. These results indicate that EECp reduced urinary bladder damage during cyclophosphamide-induced HC in rats.





Autor: Janaína P. Moraes, Denyson S. Pereira, Alexandre S. Matos, Danielle G. Santana, Cliomar A. Santos, Charles S. Estevam, Rica

Fuente: https://www.hindawi.com/



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