Nomogram Prediction of Anastomotic Leakage and Determination of an Effective Surgical Strategy for Reducing Anastomotic Leakage after Laparoscopic Rectal Cancer SurgeryReportar como inadecuado




Nomogram Prediction of Anastomotic Leakage and Determination of an Effective Surgical Strategy for Reducing Anastomotic Leakage after Laparoscopic Rectal Cancer Surgery - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Gastroenterology Research and Practice - Volume 2017 2017, Article ID 4510561, 8 pages - https:-doi.org-10.1155-2017-4510561

Research ArticleDepartment of Surgery, Chonnam National University Hwasun Hospital and Medical School, Hwasun, Chonnam, Republic of Korea

Correspondence should be addressed to Hyeong Rok Kim

Received 19 January 2017; Revised 20 March 2017; Accepted 27 March 2017; Published 16 May 2017

Academic Editor: Fernando de la Portilla

Copyright © 2017 Chang Hyun Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Although many surgical strategies have been used to reduce the anastomotic leak AL rate after laparoscopic rectal cancer surgery, limited data are available on the risk factors for AL and the effective strategy to reduce AL. Methods. The present study enrolled 736 consecutive patients who underwent laparoscopic resection without a diverting stoma for rectal adenocarcinoma. A nomogram was constructed to predict AL. Based on the nomogram, personalized risk was calculated and sequential surgical strategies were monitored using risk-adjusted cumulative sum RA-CUSUM analysis. Results. Among the 736 patients, clinical AL occurred in 65 patients 8.8%. Sex, an American Society of Anesthesiologists score, operation time, blood transfusion, and tumor location were identified as significant predictive factors for AL. Based on these factors, a nomogram was created to predict AL, with a concordance index C-index of 0.753 95% confidence interval, 0.690–0.816. A calibration plot showed good statistical performance on internal validation bias-corrected C-index of 0.742. The RA-CUSUM curve showed that extended splenic flexure mobilization SFM could be the most influential strategy to reduce AL. Conclusions. Our nomogram for predicting AL after laparoscopic rectal cancer surgery might be helpful to identify the individual risk of AL. Furthermore, extended SFM might be the most appropriate strategy for reducing AL.





Autor: Chang Hyun Kim, Soo Young Lee, Hyeong Rok Kim, and Young Jin Kim

Fuente: https://www.hindawi.com/



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