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Case Reports in Medicine - Volume 2014 2014, Article ID 439830, 4 pages -

Case Report

Department of Neurosurgery, Schleswig-Holstein Medical University in Kiel, Arnold-Heller Strasse 3, Haus 41, 24105 Kiel, Germany

Institute of Pathology, Children’s Tumor Registry, Schleswig-Holstein Medical University in Kiel, Arnold-Heller Strasse 3, Haus 14, 24105 Kiel, Germany

Department of Pediatrics, Schleswig-Holstein Medical University in Kiel, Arnold-Heller Strasse 3, Haus 9, 24105 Kiel, Germany

Received 2 September 2014; Accepted 8 December 2014; Published 29 December 2014

Academic Editor: Mark E. Shaffrey

Copyright © 2014 Andreas M. Stark et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Medulloblastoma, astrocytoma, and ependymoma represent the most common infratentorial tumors in childhood, while Ewing sarcomas in that localization are extremely rare. A large left infratentorial space-occupying lesion was diagnosed in a 12-year-old girl with signs of increased intracranial pressure. Following total tumor resection, histological and molecular examination revealed Ewing sarcoma with rearranged EWSR-1 gene. The patient achieved complete remission following adjuvant chemotherapy and radiotherapy according to Euro-EWING 2008 treatment protocol. Intracranial Ewing sarcoma, although rare, should be an important differential diagnosis of intracranial tumors in childhood which requires aggressive multimodal treatment.





Autor: Andreas M. Stark, Ivo Leuschner, H. Maximilian Mehdorn, and Alexander Claviez

Fuente: https://www.hindawi.com/



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