Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999–2002Reportar como inadecuado

Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999–2002 - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Environmental Health

, 7:27

First Online: 03 June 2008Received: 28 January 2008Accepted: 03 June 2008DOI: 10.1186-1476-069X-7-27

Cite this article as: Hatch, E.E., Nelson, J.W., Qureshi, M.M. et al. Environ Health 2008 7: 27. doi:10.1186-1476-069X-7-27


BackgroundAlthough diet and activity are key factors in the obesity epidemic, laboratory studies suggest that endocrine disrupting chemicals may also affect obesity.

MethodsWe analyzed associations between six phthalate metabolites measured in urine and body mass index BMI and waist circumference WC in National Health and Nutrition Examination Survey NHANES participants aged 6–80. We included 4369 participants from NHANES 1999–2002, with data on mono-ethyl MEP, mono-2-ethylhexyl MEHP, mono-n-butyl MBP, and mono-benzyl MBzP phthalate; 2286 also had data on mono-2-ethyl-5-hydroxyhexyl MEHHP and mono-2-ethyl-5-oxohexyl MEOHP phthalate 2001–2002. Using multiple regression, we computed mean BMI and WC within phthalate quartiles in eight age-gender specific models.

ResultsThe most consistent associations were in males aged 20–59; BMI and WC increased across quartiles of MBzP adjusted mean BMI = 26.7, 27.2, 28.4, 29.0, p-trend = 0.0002, and positive associations were also found for MEOHP, MEHHP, MEP, and MBP. In females, BMI and WC increased with MEP quartile in adolescent girls adjusted mean BMI = 22.9, 23.8, 24.1, 24.7, p-trend = 0.03, and a similar but less strong pattern was seen in 20–59 year olds. In contrast, MEHP was inversely related to BMI in adolescent girls adjusted mean BMI = 25.4, 23.8, 23.4, 22.9, p-trend = 0.02 and females aged 20–59 adjusted mean BMI = 29.9, 29.9, 27.9, 27.6, p-trend = 0.02. There were no important associations among children, but several inverse associations among 60–80 year olds.

ConclusionThis exploratory, cross-sectional analysis revealed a number of interesting associations with different phthalate metabolites and obesity outcomes, including notable differences by gender and age subgroups. Effects of endocrine disruptors, such as phthalates, may depend upon endogenous hormone levels, which vary dramatically by age and gender. Individual phthalates also have different biologic and hormonal effects. Although our study has limitations, both of these factors could explain some of the variation in the observed associations. These preliminary data support the need for prospective studies in populations at risk for obesity.

AbbreviationsBMIBody mass index

CDCCenters for Disease Control and Prevention

CIsconfidence intervals

LODlimit of detection

LOESSlocally weighted regression smoother

MEPmono-ethyl phthalate

MEHPmono-2-ethylhexyl phthalate

MBPmono-n-butyl phthalate

MBzPmono-benzyl phthalate

MEHHPmono-2-ethyl-5-hydroxyhexyl phthalate

MEOHPmono-2-ethyl-5-oxohexyl phthalate

NHANESNational Health and Nutrition Examination Survey

PPARsperoxisome proliferator-activated receptors

SESsocioeconomic status

USDAUnited States Department of Agriculture

WCwaist circumference

Electronic supplementary materialThe online version of this article doi:10.1186-1476-069X-7-27 contains supplementary material, which is available to authorized users.

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Autor: Elizabeth E Hatch - Jessica W Nelson - M Mustafa Qureshi - Janice Weinberg - Lynn L Moore - Martha Singer - Thomas F W


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